Carcinogens are mutagens: their detection and classification.
نویسندگان
چکیده
منابع مشابه
Carcinogens are mutagens: their detection and classification.
We detect mutagens by using a special set of bacterial tester strains. We have described our test system for mutagen and carcinogen detection in a series of recent papers. I will give here only a summary of some of these results, omitting references to other work, which is credited in our original papers. A simple procedure for combining human (or rat) liver for carcinogen activation and the ba...
متن کاملRapid detection of mutagens and carcinogens.
SUMMARY Bacteria deficient in DNA polymerase are much more sensitive to agents that alter cellular DNA than the parent strain from which they were derived. Advantage can be taken of this greater sensitivity to screen for potential mutagens and carcinogens.
متن کاملAn improved bacterial test system for the detection and classification of mutagens and carcinogens.
We previously described a set of four strains of Salmonella typhimurium designed for detecting the various types of mutagens, and showed their utility in detecting a wide variety of carcinogens as mutagens. The lipopolysaccharide that normally coats these bacteria is a barrier to penetration of mutagens to the cell membrane. The set of tester strains has been improved by adding a mutation (rfa:...
متن کاملDetection and identification of mutagens and carcinogens as their adducts with guanosine derivatives.
For use in screening for environmental mutagens and carcinogens, a highly fluorescent derivative of guanosine, 2'-deoxy-2'-(2",3"-dihydro-2",4"-diphenyl-2"-hydroxy-3"-oxo-1"-pyrrol yl) guanosine (FG), was synthesized. When incubated with FG in aqueous solution, mutagens form adducts that can be analyzed with an HPLC-fluorescence detector-system. By this method, mutagens such as glyoxal, methylg...
متن کاملCarcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.
18 Carcinogens, including aflatoxin B(1), benzo(a)pyrene, acetylaminofluorene, benzidine, and dimethylamino-trans-stilbene, are shown to be activated by liver homogenates to form potent frameshift mutagens. We believe that these carcinogens have in common a ring system sufficiently planar for a stacking interaction with DNA base pairs and a part of the molecule capable of being metabolized to a...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1973
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.7306115